Endocrine Abstracts

Acromegaly triggers, and is associated with, peripheral nervous system modifications and joint degenerations, which are considered to impact the walking balance of patients with acromegaly (PWA). Therefore, to better understand if these systemic degenerations impact the transitory adaptations in locomotor patterns of these patients, this study aims to establish the walking balance deficits of PWA. Walking balance was evaluated in PWA (n=8) in biochemical remission and...

Acromegaly, characterized by growth hormone excess, adversely affects the patients’ musculoskeletal and neural systems, consequently impairing physical function. Previous studies have noted walking impairments in patients with acromegaly (PWA). This study aimed to characterize the kinematic and kinetic changes during walking in PWA. Kinematics and kinetics of walking were evaluated in PWA (n=8) in biochemical remission and a control group of patients with non-fun...

The incidence of non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, continues to rise. NAFLD is associated with significant liver-specific and cardiovascular morbidity and mortality, including hepatocellular carcinoma (HCC). Currently, there are no licensed therapies, highlighting the importance of understanding the pathogenic mechanisms that drive the condition. Cytochrome p450 oxidoreductase (POR) plays an essential role in activa...

Introduction: Lutetium-177 Oxodotreotide (Lutathera) is a targeted molecular radiotherapy treatment for advanced, inoperable, progressive neuro-endocrine tumours. We present our experience of Lutathera therapy with particular focus on our experience implementing treatment as a day-case procedure, and assessment of adherence to treatment quality standards surrounding the administration.Aims: To assess safety of Lutathera as a day-case treatment.<p cla...

Purpose: There are sporadic reports illustrating more severe TED and complications in those with diabetes mellitus (DM) and from local experience these patients have poorer outcomes as seen in other diseases, such as cardiovascular disease. However, the relationship between glycaemia and clinical activity/severity and disease course are not well described.Methods: A multi-centre retrospective patient-cohort study of 236 patients referred to three TED mul...

Purpose: There is increasing evidence that a multidisciplinary (MDT) approach optimises diagnosis and management in active Thyroid Eye Disease (TED) and is recommended by current TEAMeD-5 guidelines1. Here we aim to describe the clinical and endocrine characteristics of a large cohorts of patients with TED seen in 3 MDT clinics in London.Methods: A retrospective patient-cohort study of 236 patients with suspected TED referred to these services...

Aims/objectives: The aim of this retrospective audit on MANAGEMENT OF ACUTE CHARCOT ARTHROPATHY was to assess the current practice at King’s Mill hospital against the latest National institute of clinical excellence guidelines.Methods: A retrospective audit of 22 patients with diabetes presented with acute Charcot neuro-arthropathy, between January 2016 and August 2018 to the specialist diabetes foot team at KMH. The data was collected from the hosp...

Bile acids (BA) are potent steroid hormones that mediate a variety of metabolic effects. They play a pivotal role in cholesterol catabolism, intestine nutrient absorption, and regulate lipid, glucose and energy metabolism. 5-Beta-Reductase (AKR1D1) is a key enzyme in the BA synthesis pathway, required for cholesterol metabolism into bile acids. We generated a novel global AKR1D1 knockout (KO) mouse which, as expected, has decreased total serum and hepatic BAs and altered BA co...

Steroid hormones and bile acids are potent regulators of metabolism. The enzyme 5β-reductase (AKR1D1) has a crucial role in bile acid synthesis and also generates 5β-reduced dihydrosteroid metabolites, regulating intra-cellular steroid availability though the clearance of cortisol, testosterone, androstenedione, and progesterone. As AKR1D1 sits at the interface of bile acid synthesis and steroid metabolism, we have hypothesised that it plays a key role in metabolic h...

Background: The aim of this study was to assess the association between tissue inhibitor of metalloproteinase-3 (TIMP-3) gene expression and B-Raf Proto-Oncogene (BRAF) V600E mutation in marginal and tumoral tissues of papillary thyroid carcinoma (PTC) patients.Methods: Sixty fresh frozen tissues of PTC including 55.3% women were collected during thyroidectomy surgery. All clinicopathologic features of subjects were collected which confirmed by a patholo...